Part I Basic Principles in the Diagnosis and Management of Infectious Diseases --- Section A. Microbial Pathogenesis --- A Molecular Perspective of Microbial Pathogenicity -- Microbiome of Local Sites and their Unique Biology -- Prebiotics, Probiotics and Synbiotics --- Section B. Host Defense Mechanisms -- Innate (General or Nonspecific) Host Defense Mechanisms -- Adaptive Immunity: Antibodies and Immunodefiencies -- Mucosal Immunity -- Granulocytic Phagocytes and Deficiency States -- Complement and Deficiencies -- Human Genetics and Infection -- Nutrition, Immunity, and Infection -- Evaluation of the Patient with Suspected Immunodeficiency and Other Host Defense Defects --- Section C. Epidemiology of Infectious Disease -- Epidemiologic Principles -- Emerging and Reemerging Infectious Disease Threat -- Bioterrorism: An Overview --- Section D. Clinical Microbiology -- The Clinician and the Microbiology Laboratory --- Section E. Anti-Infective Therapy -- Principles of Anti-infective Therapy -- Molecular Mechanisms of Antibiotic Resistance in Bacteria -- Pharmacokinetics and Pharmacodynamics of Anti-infective Agents Penicillins Cephalosporins -- Other ß-Lactam Antibiotics -- Antibiotic Allergy -- Fusidic Acid Aminoglycosides -- Tetracyclines and Chloramphenicol Rifamycins Metronidazole -- Macrolides, Clindamycin, and Ketolides -- Glycopeptides (Vancomycin and Teicoplanin), Streptogramins (Quinupristin-Dalfopristin), and Lipopeptides (Daptomycin) -- Polymyxins (Polymyxin B and Colistin) Oxazolidinones -- Sulfonamides and Trimethoprim Quinolones -- Unique Antibacterial Agents -- Urinary Tract Agents: Nitrofurantoin and Methenamine -- Topical Antibacterials -- Antimycobacterial Agents -- Drugs Active Against Fungi, Pneumocystis and Microsporidia -- Drugs for Malaria -- Drugs for Parasites Other Than Malaria -- Drugs for Helminths -- Antiviral Drugs General Principles -- Antivirals Against Influenza and Other Respiratory Viruses -- Antivirals Against Herpes Viruses -- Antivirals Against Hepatitis Viruses -- Other Antiviral Drugs Immunomodulators -- Hyperbaric Oxygen -- Complementary and Alternative Medicines for Infectious Diseases -- Antimicrobial Management: Cost and Resistance -- Interpretation of Clinical Trials of Antimicrobial Agents -- Outpatient Parenteral Antimicrobial Therapy -- Tables of Antimicrobial Agent Pharmacology ----- Part II Major Clinical Syndromes --- Section A. Fever -- Temperature Regulation and the Pathogenesis of Fever -- Fever of Unknown Origin -- The Acutely Ill Patient with Fever and Rash ---Section B. Upper Respiratory Tract Infections -- The Common Cold Pharyngitis -- Acute Laryngitis -- Acute Laryngotracheobronchitis (Croup) -- Otitis Externa, Otitis Media, and Mastoiditis Sinusitis Epiglottitis -- Infections of the Oral Cavity, Neck, and Head --- Section C. Pleuropulmonary and Bronchial Infections -- Acute Bronchitis -- Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, and Acute Exacerbations Bronchiolitis -- Acute Pneumonia -- Empyema and Pleural Effusion -- Lung Abscess -- Chronic Pneumonia -- Cystic Fibrosis --- Section D. Urinary Tract Infections -- Urinary Tract Infections --- Section E. Sepsis -- Sepsis, Severe Sepsis, and Septic Shock -- Section F. Intra-Abdominal Infection -- Peritonitis and Intraperitoneal Abscesses -- Infections of the Liver and Biliary System -- Pancreatic Infections -- Splenic Abscess Appendicitis -- Diverticulitis and Typhlitis --- Section G. Cardiovascular Infections -- Endocarditis and Intravascular Infections -- Prosthetic Valve Endocarditis -- Infections of Non-Valvular Cardiovascular Devices -- Prophylaxis of Infective Endocarditis -- Myocarditis and Pericarditis Mediastinitis --- Section H. Central Nervous System Infections -- Approach to the Patient with Central Nervous System Infection -- Acute Meningitis -- Chronic Meningitis -- Encephalitis, Myelitis, and Neuritis -- Brain Abscess -- Subdural Empyema, Epidural Abscess, and Intracranial Suppurative Thrombophlebitis -- Cerebrospinal fluid shunt infections --- Section I. Skin and Soft Tissue Infections -- Cellulitis, Necrotizing Fasciitis and Subcutaneous Tissue Infections Myositis -- Lymphadenitis and Lymphangitis --- Section J. Gastrointestinal Infections and Food Poisoning -- Principles and Syndromes of Enteric Infection Esophagitis -- Nausea, Vomiting, and Noninflammatory Diarrhea -- Inflammatory Enteritides -- Enteric Fever and Other Causes of Abdominal Symptoms with Fever -- Food Poisoning -- Tropical Sprue/Enteropathy --- Section K. Bone and Joint Infections -- Infectious Arthritis Osteomyelitis -- Orthopedic Implant Infections --- Section L. Diseases of the Reproductive Organs and Sexually Transmitted Diseases -- Genital Skin and Mucous Membrane Lesions Urethritis -- Vulvovaginitis and Cervicitis -- Infections of the Female Pelvis -- Prostatitis, Epididymitis, and Orchitis --- Section M. Eye Infections -- Introduction to Ocular Infections -- Microbial Conjunctivitis -- Microbial Keratitis Endophthalmitis -- Infectious Causes of Uveitis -- Periocular Infections --- Section N. Hepatitis Hepatitis --- Section O. Acquired Immunodeficiency Syndrome -- Global Perspectives on Human Immunodeficiency Virus Infection and Acquired Immunodeficiency Syndrome -- Epidemiology and Prevention of Acquired Immunodeficiency Syndrome and Human Immunodeficiency Virus Infection -- Diagnosis of Human Immunodeficiency Virus Infection -- The Immunology of Human Immunodeficiency Virus Infection -- General Clinical Manifestations of Human Immunodeficiency Virus Infection (Including the Acute Retroviral Syndrome and Oral, Cutaneous, Renal, Ocular, Metabolic and Cardiac Diseases) -- Pulmonary Manifestations of Human Immunodeficiency Virus Infection -- Gastrointestinal and Hepatobiliary Manifestations of Human Immunodeficiency Virus Infection -- Neurologic Diseases Caused by Human Immunodeficiency Virus-1 and Opportunistic Infections -- Human Immunodeficiency Virus Infection in Women -- Pediatric Human Immunodeficiency Virus Infection -- Antiretroviral Therapy for Human Immunodeficiency Virus Infection -- Management of Opportunistic Infections Associated with Human Immunodeficiency Virus Infection -- Vaccines for Human Immunodeficiency Virus-1 Infection --- Section P. Miscellaneous Syndromes -- Chronic Fatigue Syndrome ---- Part III Infectious Diseases and Their Etiologic Agents --- Section A. Viral Diseases -- Biology of Viruses and Viral Diseases -- Orthopoxviruses: Vaccinia (Smallpox Vaccine), Variola (Smallpox), Monkeypox, and Cowpox -- Other Poxviruses That Infect Humans: Parapoxviruses, Molluscum Contagiosum, and Tanapox --- Section B. Herpesviridae -- Introduction to Herpesviridae -- Herpes Simplex Virus -- Chickenpox and Herpes Zoster (Varicella-Zoster Virus) Cytomegalovirus -- Epstein-Barr Virus (Infectious Mononucleosis) -- Human Herpesvirus Types 6 and 7 -- Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus Type 8) -- Herpes B Virus --- Section C. Adenoviridae Adenovirus --- Section D. Papovaviridae Papillomaviruses -- JC, BK, and Other Polyomaviruses; Progressive Multifocal Leukoencephalopathy Hepadnaviridae -- Hepatitis B Virus and Hepatitis Delta Virus

Section E. Parvoviridae -- Human Parvoviruses -- Orthoreoviruses, Orbiviruses, Coltiviruses -- Seadornaviruses (Colorado Tick Fever) Rotaviruses -- Alphaviruses, Including Chickungunya -- Rubella Virus (German Measles) ---- PART IV. Flaviviruses -- Flaviviruses (Yellow Fever, Dengue, Dengue Hemorrhagic Fever, Japanese Encephalitis, West Nile Encephalitis, St. Louis Encephalitis, Tick-Borne Encephalitis) -- Hepatitis C --- Section A. Coronaviridae -- Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS)-Associated Coronavirus -- Section B. Paramyxoviridae -- Parainfluenza Viruses -- Mumps Virus -- Respiratory Syncytial Virus -- Human Metapneumovirus -- Measles Virus (Rubeola) -- Zoonotic Paramyxoviruses: Hendra, Nipah, and Menangle Viruses --- Section C. Rhabdoviridae -- Vesicular Stomatitis Virus and Related Viruses -- Rabies (Rhabdoviruses) --- Section D. Filoviridae -- Marburg and Ebola Virus Hemorrhagic Fevers --- Section E. Orthomyxoviridae -- Influenza Viruses Including Avian Influenza -- Section F. Bunyaviridae --- California Encephalitis, Hantavirus Pulmonary Syndrome, and Bunyavirid Hemorrhagic Fevers --- Section G. Arenaviridae -- Lymphocytic Choriomeningitis Virus, Lassa Virus, and the South American Hemorrhagic Fevers --- Section H. Retroviridae -- Human T-Cell Lymphotropic Virus Types I and II -- Human Immunodeficiency Viruses --- Section I. Picornaviridae -- Introduction to the Enteroviruses Poliovirus -- Coxsackieviruses, Echoviruses, and Newer Enteroviruses Parechoviruses -- Hepatitis A Virus Rhinovirus ---- PART V. Caliciviridae and Other Gastrointestinal Viruses --Noroviruses and Other Caliciviruses -- Astroviruses and Picobirnaviruses --- Section A. Unclassified Viruses -- Hepatitis E Virus --- Section B. Prion Diseases -- Prions and Prion Diseases of the Central Nervous System (Transmissible Neurodegenerative Diseases) --- Section C. Chlamydial Diseases -- Chlamydia trachomatis (Trachoma, Perinatal Infections, Lymphogranuloma Venereum, and Other Genital Infections) -- Chlamydophila (Chlamydia) Psittaci (Psittacosis) -- Chlamydia Pneumoniae -- Mycoplasma Pneumoniae and Atypical Pneumonia --- Section D. Mycoplasma Diseases -- Genital Mycoplasmas: Mycoplasma genitalium, Mycoplasma hominis, and Ureaplasma Species --- Section E. Rickettsioses, Ehrlichioses, and Anaplasmosis -- Introduction to Rickettsioses, Ehrlichioses and Anaplasmosis -- Rickettsia Rickettsii and Other Spotted Fever Group Rickettsiae (Rocky Mountain Spotted Fever and Other Spotted Fevers) -- Rickettsia Akari (Rickettsialpox) -- Coxiella Burnetii (Q Fever) -- Rickettsia Prowazekii (Epidemic or Louse-Borne Typhus) -- Rickettsia typhi (Murine Typhus) -- Orientia Tsutsugamushi -- Ehrlichia Chaffeensis and Ehrlichia Phagocytophila --- Section F. Bacterial Diseases -- Introduction to Bacteria and Bacterial Diseases --- Section G. Gram-Positive Cocci -- Staphylococcus aureus (Including Staphylococcal Toxic Shock) -- Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci -- Classification of Streptococci -- Streptococcus Pyogenes -- Nonsuppurative Poststreptococcal Sequelae: Rheumatic Fever and Glomerulonephritis -- Streptococcus pneumonia -- Enterococcus Species, Streptococcus bovis, and Leuconostoc Species -- Streptococcus agalactiae (Group B Streptococcus) -- Viridans Streptococci, Groups C and G Streptococci, and Gemella morbillorum -- Streptococcus anginosus Group --- Section H. Gram-Positive Bacilli -- Corynebacterium diphtheria -- Corynebacteria other than Diphtheria and Rhodococcus -- Listeria Monocytogenes -- Bacillus Anthracis (Anthrax) -- Bacillus Species and Other than Bacillus anthracis -- Erysipelothrix Rhusiopathiae -- Whipple's Disease --- Section I. Gram-Negative Cocci -- Neisseria Meningitidis -- Neisseria Gonorrhoeae -- Moraxella Catarrhalis and Other Gram-Negative Cocci --- Section J. Gram-Negative Bacilli -- Vibrio Cholerae -- Other Pathogenic Vibrios -- Campylobacter Jejuni and Related Species -- Helicobacter Pylori and Other Gastric Helicobacter Species Enterobacteriaceae -- Pseudomonas Species, Including Ps. Aeruginosa -- Stenotrophomonas Maltophilia and Burkholderia Cepacia Complex -- Burkholderia Pseudomallei and Burkholderia Mallei -- Acinetobacter Species -- Salmonella Species, Including Salmonella Typhi -- Shigella Species (Bacillary Dysentery) -- Haemophilus Species (including H. Influenzae and Chancroid) -- Brucella Species -- Francisella Tularensis (Tularemia) -- Pasteurella Species -- Yersinia Species, Including Plague -- Bordetella Pertussis -- Rat-Bite Fever Streptobacillus Moniliformis and Spirillum Minus -- Legionella and Other Legionella Species Capnocytophaga -- Bartonella, Including Cat-Scratch Disease -- Calymmatobacterium Granulomatis (Donovanosis, Granuloma Inguinale) -- Other Gram-Negative and Gram-Variable Bacilli --- Section K. Spirochetes -- Treponema pallidum (Syphilis) -- Endemic Treponematoses -- Leptospira Species (leptospirosis) -- Relapsing Fevers Due to Borrelia Species -- Borrelia burgdorferi (Lyme Disease, Lyme Borreliosis) --- Section L. Anaerobic Bacteria -- Anaerobic Infections: General Concepts -- Clostridium Difficile -- Clostridium Tetani (Tetanus) -- Clostridium Botulinum (Botulism) -- Gas Gangrene and Other Clostridium-Associated Diseases -- Bacteroides, Prevotella, Porphyromonas, and Fusobacterium Species (and Other Medically Important Anaerobic Gram-Negative Bacilli) -- Anaerobic Cocci and Anaerobic Gram-Positive Non-sporulating Bacilli --- Section M. Mycobacterial Diseases -- Mycobacterium Tuberculosis ---Mycobacterium Leprae -- Mycobacterium Avium-Intracellulare -- Nontuberculous Mycobacteria Other Than M. Avium-Intracellulare Complex --- Section N. Higher Bacterial Diseases -- Nocardia Species -- Agents of Actinomycosis -- Section O. Mycoses --- Introduction to Mycoses -- Candida Species -- Aspergillus Species -- Agents of Mucormycosis -- Sporothrix schenckii -- Agents of Chromomycosis -- Agents of Mycetoma -- Cryptococcus neoformans -- Histoplasma capsulatum -- Blastomyces dermatitidis -- Coccidioides Species -- Dermatophytosis and Other Superficial Mycoses -- Paracoccidioides brasiliensis -- Uncommon Fungi and Prototheca -- Pneumocystis -- Microsporidiosis --- Section H. Protozoal Diseases -- Introduction to Protozoal Diseases -- Entamoeba species including amoebiasis -- Free-Living Amebas -- Plasmodium Species (Malaria) -- Leishmania Species: Visceral (Kala-Azar), Cutaneous, and Mucocutaneous Leishmaniasis -- Biology of Trypanosoma Species (American Trypanosomiasis, Chagas' Disease): Biology of Trypanosomes -- Agents of African Trypanosomiasis (Sleeping Sickness) -- Toxoplasma gondii -- Giardia lamblia -- Trichomonas vaginalis -- Babesia Species -- Cryptosporidium Species -- Isospora belli, Sarcocystis Species, Blastocystis hominis and Cyclospora --- Section I. Diseases Due to Toxic Algae -- Human Illness Associated with Harmful Algal Blooms --- Section J. Diseases Due to Helminths -- Introduction to Helminth Infections -- Intestinal Nematodes (Roundworms) -- Tissue Nematodes, Including Trichinosis, Dracunculiasis, and the Filariases -- Trematodes (Schistosomes and Other Flukes) -- Cestodes (Tapeworms) -- Visceral Larva Migrans and Other Unusual Helminth Infections --- Section K. Ectoparasitic Diseases -- Introduction to Ectoparasitic Diseases -- Lice (Pediculosis) Scabies -- Myiasis and Tungiasis -- Mites (Including Chiggers) -- Ticks (Including Tick Paralysis) --- Section L. Diseases of Unknown Etiology -- Kawasaki Disease ---- Part IV Special Problems --- Section A. Nosocominal Infections -- Organization for Infection Control and Isolation -- Disinfection, Sterilization, and Control of Hospital Waste -- Infections Caused by Percutaneous Intravascular Devices -- Nosocomial Pneumonia -- Nosocomial Urinary Tract Infections -- Nosocomial Hepatitis -- Infections Transmitted by Transfusion and Transplantation -- Human Immunodeficiency Virus in Health Care Settings -- Nosocomial Herpesvirus Infections --- Section B. Infections in Special Hosts -- Infections in the Immunocompromised Host: General Principles -- Prophylaxis and Empirical Therapy of Infection in Cancer Patients -- Risk Factors and Approaches to Infections in Transplant Recipients -- Infections in Hematopoietic Stem Cell Transplant Recipients -- Infections in Solid Organ Transplant Recipients -- Infections in Patients with Spinal Cord Injury -- Infections in the Elderly -- Infections in Asplenic Patients -- Infections in Injection Drug Users -- Postoperative Infections and Antimicrobial Prophylaxis --- Section C. Surgical and Trauma-Related Infections -- Infections in Patients with Burns -- Bites --- Section D. Immunization -- Immunization --- Section E. Zoonoses -- Zoonoses --- Section F. Protection of Travelers -- Protection of Travelers -- Infections in Returning Travelers

After thirty five years, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th Edition is still the reference of choice for comprehensive, global guidance on diagnosing and treating the most challenging infectious diseases. Drs. John E. Bennett and Raphael Dolin along with new editorial team member Dr. Martin Blaser have meticulously updated this latest edition to save you time and to ensure you have the latest clinical and scientific knowledge at your fingertips. With new chapters, expanded and updated coverage, increased worldwide perspectives, and many new contributors, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, 8th Edition helps you identify and treat whatever infectious disease you see. "I highly recommend Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, together with the included ExpertConsult, the on-line version of the book that is a searchable source and is available to a variety of platforms. It is updated twice each year and is an excellent solution for health-care professionals to keep informed of the latest knowledge" Reviewed by: Graefes Arch Clin Exp Ophthalmol Date: March 2015.